ECONOMIC RENAISSANCE: THE MASSACHUSETTS EXPERIENCE

Community/Rural/Urban Development,

The New England Economic Revitalization and Future Research Priorities

New England\u27s recent economic revitalization is largely attributed to the region\u27s success in technological innovation and adaptation. This capacity to supplant older, maturing technologies with new technologies — a willingness to continually shed the old to make room for the new — has been a characteristic of New England since the early nineteenth century. At that time, as today, the critical factors in the process of technological development were the presence of investment capital, skilled labor, entrepreneurs, and, above all, preeminent colleges and universities that foster unconventional thinking and risk-taking. While the region\u27s economy should continue to benefit from these fundamental factors, it is not without problems, and these merit additional research. The problems specified in this article all relate to maintaining the fundamentals for growth in the face of the adjustments that inevitably occur when a region undergoes periods of structural change. Nonetheless, two centuries of successful technological and manufacturing revitalization confirm the resiliency of New England\u27s economy and underscore its ability to successfully undergo periods of industrial transition and transformation

Changes in carcass microbial distribution and water conditions during the scalding and dehairing of pig carcasses

Salmonella contaminatron is of major concern in the production of pork As part of a UK Food Standards Agency project looking at reducing salmonella contamrnation, a survey of current processing conditions in UK pig slaughterhouses and a review of published data identified pork scalding and dehairing systems as a likely major source of salmonella contamination during pork processing

Sources of salmonella contamination in pig processing

The quantification of current state of the art on alternative/novel pig slaughtenng and processing procedures and pork decontamination was the initial aim of a project to reduce salmonella in pig processing for the UK Foods Standards Agency. To achieve these aims a survey of current commercial processing conditions was carried out, the published literature reviewed, and a review performed of technology from other sectors

Scalable Dashboard for Identifying Split Failures and Heuristic for Reallocating Split Times

The three fundamental parameters of a traffic signal system are split, cycle, and offset. This paper describes the use of high-resolution data (a) to identify time periods during which split parameters may be insufficient and (b) to help practitioners identify opportunities for reallocating split time. A case study of seven corridors with 47 intersections is presented. A drill-down approach was developed to identify movements that could be improved by a reallocation of split times. A heuristic that can reallocate up to 5 seconds of underutilized green time on a competing phase was applied to those corridors. For the selected phase identified in this study, the adjustment reduced split failures by an average of 40% while also decreasing yellow occupancy an average of 40% and red light violations an average of 66%. The paper concludes by recommending that central systems implement drill-down dashboards. Such tools would enable easy identification and systemwide monitoring of split failures and would provide opportunities to reallocate slack time

Quantum Mutual Information Capacity for High Dimensional Entangled States

High dimensional Hilbert spaces used for quantum communication channels offer the possibility of large data transmission capabilities. We propose a method of characterizing the channel capacity of an entangled photonic state in high dimensional position and momentum bases. We use this method to measure the channel capacity of a parametric downconversion state, achieving a channel capacity over 7 bits/photon in either the position or momentum basis, by measuring in up to 576 dimensions per detector. The channel violated an entropic separability bound, suggesting the performance cannot be replicated classically.Comment: 5 pages, 2 figure

Functional network changes and cognitive control in schizophrenia

Cognitive control is a cognitive and neural mechanism that contributes to managing the complex demands of day-to-day life. Studies have suggested that functional impairments in cognitive control associated brain circuitry contribute to a broad range of higher cognitive deficits in schizophrenia. To examine this issue, we assessed functional connectivity networks in healthy adults and individuals with schizophrenia performing tasks from two distinct cognitive domains that varied in demands for cognitive control, the RiSE episodic memory task and DPX goal maintenance task. We characterized general and cognitive control-specific effects of schizophrenia on functional connectivity within an expanded frontal parietal network (FPN) and quantified network topology properties using graph analysis. Using the network based statistic (NBS), we observed greater network functional connectivity in cognitive control demanding conditions during both tasks in both groups in the FPN, and demonstrated cognitive control FPN specificity against a task independent auditory network. NBS analyses also revealed widespread connectivity deficits in schizophrenia patients across all tasks. Furthermore, quantitative changes in network topology associated with diagnostic status and task demand were observed. The present findings, in an analysis that was limited to correct trials only, ensuring that subjects are on task, provide critical insights into network connections crucial for cognitive control and the manner in which brain networks reorganize to support such control. Impairments in this mechanism are present in schizophrenia and these results highlight how cognitive control deficits contribute to the pathophysiology of this illness

A large-scale pedigree resource of wheat reveals evidence for adaptation and selection by breeders

<div><p>Information on crop pedigrees can be used to help maximise genetic gain in crop breeding and allow efficient management of genetic resources. We present a pedigree resource of 2,657 wheat (<i>Triticum aestivum</i> L.) genotypes originating from 38 countries, representing more than a century of breeding and variety development. Visualisation of the pedigree enables illustration of the key developments in United Kingdom wheat breeding, highlights the wide genetic background of the UK wheat gene pool, and facilitates tracing the origin of beneficial alleles. A relatively high correlation between pedigree- and marker-based kinship coefficients was found, which validated the pedigree and enabled identification of errors in the pedigree or marker data. Using simulations with a combination of pedigree and genotype data, we found evidence for significant effects of selection by breeders. Within crosses, genotypes are often more closely related than expected by simulations to one of the parents, which indicates selection for favourable alleles during the breeding process. Selection across the pedigree was demonstrated on a subset of the pedigree in which 110 genotyped varieties released before the year 2000 were used to simulate the distribution of marker alleles of 45 genotyped varieties released after the year 2000, in the absence of selection. Allelic diversity in the 45 varieties was found to deviate significantly from the simulated distributions at a number of loci, indicating regions under selection over this period. The identification of one of these regions as coinciding with a strong yield component quantitative trait locus (QTL) highlights both the potential of the remaining loci as wheat breeding targets for further investigation, as well as the utility of this pedigree-based methodology to identify important breeding targets in other crops. Further evidence for selection was found as greater linkage disequilibrium (LD) for observed versus simulated genotypes within all chromosomes. This difference was greater at shorter genetic distances, indicating that breeder selections have conserved beneficial linkage blocks. Collectively, this work highlights the benefits of generating detailed pedigree resources for crop species. The wheat pedigree database developed here represents a valuable community resource and will be updated as new varieties are released at <a href="https://www.niab.com/pages/id/501/UK_Wheat_varieties_Pedigree" target="_blank">https://www.niab.com/pages/id/501/UK_Wheat_varieties_Pedigree</a>.</p></div

Detector-Free Optimization of Traffic Signal Offsets with Connected Vehicle Data

It has recently been shown that signal offset optimization is feasible using vehicle trajectory data at low levels of market penetration. This study performs offset optimization on two corridors using this type ofdata. Six weeks oftrajectory splines were processed for two corridors including 25 signalized intersections, in order to create vehicle arrival profiles, using a proposed procedure called virtual detection. After processing and filtering the data, penetration rates between 0.09-0.80% were observed, varying by approach. The arrival profiles were statistically compared against those measured with physical detectors, with the majority of the approaches showing statistically significant goodness-of-fit at a 90% confidence level. Finally, the virtual detection arrival profiles were used to optimize offsets, and compared against a solution derived from physical detector arrival profiles. The results demonstrate that virtual detection can produce good quality offsets with current market penetration rates of probe data. The study also includes a sensitivity analysis to the sample period, which shows that two weeks of data may be sufficient for data collection at current penetration rates

Intestinal schistosomiasis in Uganda at high altitude (>1400 m): malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs

Background Intestinal schistosomiasis is of public health importance in Uganda but communities living above 1400 m are not targeted for control as natural transmission is thought unlikely. To assess altitudinal boundaries and at-risk populations, conjoint malacological and epidemiological surveys were undertaken on Mount Elgon (1139 m–3937 m), in Fort Portal crater lakes and in the Rwenzori Mountains (1123 m–4050 m). Methods Seventy freshwater habitats [Mount Elgon (37), Fort Portal crater lakes (23), Rwenzori Mountains (8) and Lake Albert (2)] were inspected for Biomphalaria species. Water temperature, pH and conductivity were recorded. A parasitological examination of 756 schoolchildren [Mount Elgon (300), Fort Portal crater lakes (456)] by faecal microscopy of duplicate Kato-Katz smears from two consecutive stool samples was bolstered by antigen (urine-CCA dipstick) and antibody (SEA-ELISA) diagnostic assays. Results Biomphalaria spp. was found up to 1951 m on Mount Elgon and 1567 m in the Fort Portal crater lakes. Although no snail from Mount Elgon shed cercariae, molecular analysis judged 7.1% of snails sampled at altitudes above 1400 m as having DNA of Schistosoma mansoni; in Fort Portal crater lakes three snails shed schistosome cercariae. Prevalence of intestinal schistosomiasis as measured in schoolchildren by Kato-Katz (Mount Elgon = 5.3% v. Fort Portal crater lakes = 10.7%), CCA urine-dipsticks (18.3% v. 34.4%) and SEA-ELISA (42.3% v. 63.7%) showed negative associations with increasing altitude with some evidence of infection up to 2000 m. Conclusions Contrary to expectations, these surveys clearly show that natural transmission of intestinal schistosomiasis occurs above 1400 m, possibly extending up to 2000 m. Using spatial epidemiological predictions, this now places some extra six million people at-risk, denoting an expansion of preventive chemotherapy needs in Uganda